Fig. 3

Integrated genomic analysis of somatic mutation and copy number variations of KEGG pathway cell cycle genes in KIT-mutant GIST. The integrated results from genomic copy number loss and somatic mutation analyses are shown. Genes with a deleterious single nucleotide variant* (●) in a gene within the cell cycle pathway (red font on left) or cancer pathways (black font on left) are shown with the corresponding copy number variation for the same gene (red boxes). *Exonic, non-synonymous or splicing